The U.S. Linked Donor Component Recipient Databases (Vein-to-Vein Databases)


The REDS-IV-P program will continue accumulating blood donor, donation, blood component and patient (including recipient) data in linked databases, with the new program expanded to include maternal, fetal, neonatal, and pediatric recipient populations. Participating hospitals will provide Electronic Medical Record (EMR) data on not only large volumes of adult patients admitted to services where transfusion is common (intensive care units, cardiac surgery, orthopedic surgery, oncology/cancer center, and trauma service), but also access to obstetrical, neonatal intensive care, and pediatric patients (both in and out-patient services). Multicenter, research-quality, sharable and linkable databases will be established capturing longitudinal/temporal data on blood donors and patients (transfused and non-transfused) that includes detailed demographic, clinical and laboratory data. The REDS-IV-P vein-to-vein databases will allow for database projects such as descriptive analyses, case-control, and cohort evaluations in these populations that address important transfusion research questions. Cutting-edge data science methods and “big data” tools will be applied to process, harmonize, manage, and analyze the REDS-IV-P databases.


The REDS-III domestic program established for the first time a research database infrastructure that links data from blood donors and their donations, the components made from these donations, and the recipients of these components. These cumulative databases and the ability to link donor and recipient data enabled investigators to address important issues in blood banking and transfusion medicine and to inform blood policy decisions.