REDS-III Publications
Publications
General (Phases 1 and 2)
The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III): A research program striving to improve blood donor and transfusion recipient outcomes.
Steven Kleinman MD, Michael P Busch MD, PhD, Edward L Murphy MD, MPH, Hua Shan, Paul Ness, Simone A. Glynn MD, MPH for The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III). Transfusion. 2014; 54 (No 3, Part II): 942-955; doi:10.1111/trf.12468 (PMID: 24188564)
No association between frequent apheresis donation and risk of fractures: a retrospective cohort analysis from Sweden.
Grau, K., Vasan, S. K., Rostgaard, K., Bialkowski, W., Rut, N., Hjalgrim, H., Gustaf, E., & for the National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Transfusion. 2016; 57(2):390-396. doi: 10.1111/trf.13907. Epub 2016 Nov 18. (PMID: 27859323)
High incidence of Chikungunya virus and frequency of viremic blood donations during epidemic, Puerto Rico, USA, 2014.
Simmons G, Brès V, Lu K, Liss NM, Brambilla DJ, Ryff KR, Bruhn R, Velez E, Ocampo D, Linnen JM, Latoni G, Petersen LR, Williamson PC, Busch MP. High Incidence of Chikungunya Virus and Frequency of Viremic Blood Donations during Epidemic, Puerto Rico, USA, 2014. Emerg Infect Dis. 2016 Jul;22(7):1221-8. doi: 10.3201/eid2207.160116. Epub 2016 Jul 15. PMID: 27070192 ; PMCID: PMC4918147.
Genetic Characterization of a Panel of Diverse HIV-1 Isolates at Seven International Sites.
Hora B, Keating SM, Chen Y, Sanchez AM, Sabino E, Hunt G, Ledwaba J, Hackett J Jr, Swanson P, Hewlett I, Ragupathy V, Vikram Vemula S, Zeng P, Tee KK, Chow WZ, Ji H, Sandstrom P, Denny TN, Busch MP, Gao F; REDS-III and EQAPOL programs. Genetic Characterization of a Panel of Diverse HIV-1 Isolates at Seven International Sites. PLoS One. 2016 Jun 17;11(6):e0157340. doi: 10.1371/journal.pone.0157340. PMID: 27314585; PMCID: PMC4912073.
Detection of Zika virus RNA in semen of asymptomatic blood donors.
Musso D, Richard V, Teissier A, Stone M, Lanteri MC, Latoni G, Alsina J, Reik R, Busch MP; Recipient Epidemiology and Donor Evaluation Study (REDS-III) ZIKV Study Group. Detection of Zika virus RNA in semen of asymptomatic blood donors. Clin Microbiol Infect. 2017 Dec;23(12):1001.e1-1001.e3. doi: 10.1016/j.cmi.2017.07.006. Epub 2017 Jul 13. PMID: 28711704; PMCID: PMC6016846.
A comparison of methods for estimating the incidence of human immunodeficiency virus infection in repeat blood donors.
Brambilla DJ, Busch MP, Dodd RY, Glynn SA, Kleinman SH; National Heart, Lung, and Blood InstituteRecipient Epidemiology and Donor Evaluation Study-III (REDS-III). A comparison of methods for estimating the incidence of human immunodeficiency virus infection in repeat blood donors. Transfusion. 2017 Mar;57(3pt2):823-831. doi: 10.1111/trf.13939. Epub 2016 Dec 1. (PMID: 27910095 ; PMCID: PMC5368013.
Searching for unknown transfusion-transmitted hepatitis viruses: a binational cohort study of 1.5 million transfused patients.
Edgren G, Hjalgrim H, Rostgaard K, Dahl V, Titlestad K, Erikstrup C, Wikman A, Norda R, Majeed A; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Searching for unknown transfusion-transmitted hepatitis viruses: a binational cohort study of 1.5 million transfused patients. J Intern Med. 2018 Jul;284(1):92-103. doi: 10.1111/joim.12762. Epub 2018 Apr 25. PMID: 29624755; PMCID: PMC6013371.
Association of Proton Pump Inhibitor and Histamine H2-Receptor Antagonists with Restless Legs Syndrome
Earley EJ, Didriksen M, Spencer BR, Kiss JE, Erikstrup C, Pedersen OB, Sørensen E, Burgdorf KS, Kleinman SH, Mast AE, Busch MP, Ullum H, Page GP. Association of proton pump inhibitor and histamine H2-receptor antagonists with restless legs syndrome. Sleep. 2021 Apr 9;44(4):zsaa220. doi: 10.1093/sleep/zsaa220. PMID: 33119070; PMCID: PMC8033459.
Estimating the incidence of HIV infection in repeat blood donors with low average donation frequency
Brambilla DJ, Busch MP, Glynn SA, Kleinman SH; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Estimating the incidence of HIV infection in repeat blood donors with low average donation frequency. Transfusion. 2021 Feb;61(2):494-502. doi: 10.1111/trf.16144. Epub 2020 Oct 24. PMID: 33098135.
Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress
Hazegh K, Fang F, Bravo MD, Tran JQ, Muench MO, Jackman RP, Roubinian N, Bertolone L, DʼAlessandro A, Dumont L, Page GP, Kanias T. Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress. Transfusion. 2021 Feb;61(2):435-448. doi: 10.1111/trf.16168. Epub 2020 Nov 4. PMID: 33146433; PMCID: PMC7902376.
Demographic, Clinical, and Biochemical Predictors of Pica in a Large Cohort of Blood Donors
Liu H, Burns RT, Spencer BR, Page GP, Mast AE; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III. Demographic, clinical, and biochemical predictors of pica in a large cohort of blood donors. Transfusion. 2021 Jul;61(7):2090-2098. doi: 10.1111/trf.16409. Epub 2021 Apr 29. PMID: 33913181; PMCID: PMC8571648.
Multi-ancestry genome-wide association study identifies 27 loci associated with erythrocyte osmotic fragility, oxidative or spontaneous hemolysis following blood storage
Page GP, Kanias T, Guo YJ, Lanteri MC, Zhang X, Mast AE, Cable RG, Spencer BR, Kiss JE, Fang F, Endres-Dighe SM, Brambilla D, Nouraie M, Gordeuk VR, Kleinman S, Busch MP, Gladwin MT; National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology Donor Evaluation Study–III (REDS-III) program. Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage. J Clin Invest. 2021 Jul 1;131(13):e146077. doi: 10.1172/JCI146077. PMID: 34014839; PMCID: PMC8245173.
Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice
Shim BS, Kwon YC, Ricciardi MJ, Stone M, Otsuka Y, Berri F, Kwal JM, Magnani DM, Jackson CB, Richard AS, Norris P, Busch M, Curry CL, Farzan M, Watkins D, Choe H. Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice. mBio. 2019 Jul 2;10(4):e00758-19. doi: 10.1128/mBio.00758-19. PMID: 31266863; PMCID: PMC6606798.
Zika virus RNA and IgM persistence in blood compartments and body fluids: a prospective observational study
Stone M, Bakkour S, Lanteri MC, Brambilla D, Simmons G, Bruhn R, Kaidarova Z, Lee TH, Orlando Alsina J, Williamson PC, Galel SA, Pate LL, Linnen JM, Kleinman S, Busch MP; NHLBI Recipient Epidemiology Donor Evaluation Study REDS-III Program. Zika virus RNA and IgM persistence in blood compartments and body fluids: a prospective observational study. Lancet Infect Dis. 2020 Dec;20(12):1446-1456. doi: 10.1016/S1473-3099(19)30708-X. Epub 2020 Jul 13. PMID: 32673593.
The Impact of Early Antiretroviral Treatment (ART) for HIV on the Sensitivity of the Latest Generation of Blood Screening and Point of Care Assays
Vermeulen M, van Schalkwyk C, Jacobs G, van den Berg K, Stone M, Bakkour S, Custer B, Jentsch U, Busch MP, Murphy E, Grebe E. The Impact of Early Antiretroviral Treatment (ART) for HIV on the Sensitivity of the Latest Generation of Blood Screening and Point of Care Assays. Viruses. 2022 Jun 29;14(7):1426. doi: 10.3390/v14071426. PMID: 35891406; PMCID: PMC9324335.
Phase 1 – Domestic
Trends in Red Blood Cell Transfusion and 30-Day Mortality among Hospitalized Patients.
Roubinian NH, Escobar GJ, Liu V, Swain BE, Gardner MN, Kipnis P, Triulzi DJ, Gottschall JL, Wu Y, Carson JL, Kleinman SH, Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III). Trends in red blood cell transfusion and 30-day mortality among hospitalized patients. Transfusion. 2014 Oct;54(10 Pt 2):2678-86. doi: 10.1111/trf.12825. Epub 2014 Aug 18. PMID: 25135770 ; PMCID: PMC4197097.
Predicting Red Blood Cell Transfusion in Hospitalized Patients: Role of Hemoglobin Level, Comorbidities, and Illness Severity.
Roubinian NH, Murphy EL, Swain BE, Gardner MN, Liu V, Escobar GJ; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III); Northern California Kaiser Permanente DOR Systems Research Initiative. Predicting red blood cell transfusion in hospitalized patients: role of hemoglobin level, comorbidities, and illness severity. BMC Health Serv Res. 2014 May 10;14:213. doi: 10.1186/1472-6963-14-213. PMID: 24884605; PMCID: PMC4101854.
Decreased Red Blood Cell Use and Mortality in Hospitalized Patients.
Roubinian NH, Escobar GJ, Liu V, Gardner MN, Carson JL, Kleinman SH, Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III). Decreased red blood cell use and mortality in hospitalized patients. JAMA Intern Med. 2014 Aug;174(8):1405-7. doi: 10.1001/jamainternmed.2014.2889. PMID: 24978650; PMCID: PMC4445732.
Downregulation of Cytokines and Chemokines by GB Virus C After Transmission Via Blood Transfusion in HIV-Positive Blood Recipients.
Lanteri MC, Vahidnia F, Tan S, Stapleton JT, Norris PJ, Heitman J, Deng X, Keating SM, Brambilla D, Busch MP, Custer B; NHLBI REDS III Study. Downregulation of Cytokines and Chemokines by GB Virus C After Transmission Via Blood Transfusion in HIV-Positive Blood Recipients. J Infect Dis. 2015 May 15;211(10):1585-96. doi: 10.1093/infdis/jiu660. Epub 2014 Nov 25. PMID: 25425697; PMCID: PMC4481614.
Oral Iron Supplementation After Blood Donation: A Randomized Clinical Trial
Kiss JE, Brambilla D, Glynn SA, Mast AE, Spencer BR, Stone M, Kleinman SH, Cable RG; National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study–III (REDS-III). Oral iron supplementation after blood donation: a randomized clinical trial. JAMA. 2015 Feb 10;313(6):575-83. doi: 10.1001/jama.2015.119. PMID: 25668261; PMCID: PMC5094173.
Effect of iron supplementation on iron stores and total body iron after whole blood donation.
Cable RG, Brambilla D, Glynn SA, Kleinman S, Mast AE, Spencer BR, Stone M, Kiss JE; National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Effect of iron supplementation on iron stores and total body iron after whole blood donation. Transfusion. 2016 Aug;56(8):2005-12. doi: 10.1111/trf.13659. Epub 2016 May 27. PMID: 27232535; PMCID: PMC4980154.
A multicenter study of plasma use in the United States.
Triulzi D, Gottschall J, Murphy E, Wu Y, Ness P, Kor D, Roubinian N, Fleischmann D, Chowdhury D, Brambilla D; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). A multicenter study of plasma use in the United States. Transfusion. 2015 Jun;55(6):1313-9; quiz 1312. doi: 10.1111/trf.12970. Epub 2014 Dec 19. PMID: 25522888; PMCID: PMC4968201.
Blood donor deferral for men who have sex with men: the Blood Donation Rules Opinion Study (Blood DROPS).
Custer B, Sheon N, Siedle-Khan B, Pollack L, Spencer B, Bialkowski W, D’Andrea P, Sullivan M, Glynn S, Williams A; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Blood donor deferral for men who have sex with men: the Blood Donation Rules Opinion Study (Blood DROPS). Transfusion. 2015 Dec;55(12):2826-34. doi: 10.1111/trf.13247. Epub 2015 Jul 22. PMID: 26202349; PMCID: PMC4715553.
Feasibility of routine ferritin testing for donor management: Validation of delayed processing and demonstration of within donor reproducibility over time.
Stone M, Brambilla D, Murcia K, Dimapasoc M, Cyrus S, Cable RG, Kiss JE, Busch MP; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Feasibility of routine ferritin testing for donor management: validation of delayed processing and demonstration of within donor reproducibility over time. Transfusion. 2016 Oct;56(10):2422-2425. doi: 10.1111/trf.13793. PMID: 27739151.
Saving lives, maintaining safety, and science-based policy: qualitative interview findings from the Blood Donation Rules Opinion Study (Blood DROPS).
Hughes S, Sheon N, Siedle-Khan B, Custer B. Saving lives, maintaining safety, and science-based policy: qualitative interview findings from the Blood Donation Rules Opinion Study (Blood DROPS). Transfusion. 2015 Dec;55(12):2835-2841. doi: 10.1111/trf.13268. Epub 2015 Aug 14. PMID: 26271755; PMCID: PMC4715561.
Genomewide association study of HLA alloimmunization in previously pregnant blood donors
Seielstad M, Page GP, Gaddis N, Lanteri M, Lee TH, Kakaiya R, Barcellos LF, Criswell LA, Triulzi D, Norris PJ, Busch MP; NHLBI REDS-III Study Investigators. Genomewide association study of HLA alloimmunization in previously pregnant blood donors. Transfusion. 2018 Feb;58(2):402-412. doi: 10.1111/trf.14402. Epub 2017 Nov 22. PMID: 29168253; PMCID: PMC5803399.
Brazil (Phases 1 and 2)
Blood utilization and characteristics of patients treated with chronic transfusion therapy in a large cohort of Brazilian patients with sickle cell disease.
Kelly S, Belisário AR, Werneck Rodrigues DO, Carneiro-Proietti ABF, Gonçalez TT, Loureiro P, Flor-Park MV, Maximo C, Mota RA, Dinardo C, Brambilla D, Preiss L, Sabino E, Custer B; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS-III) International Component-Brazil. Blood utilization and characteristics of patients treated with chronic transfusion therapy in a large cohort of Brazilian patients with sickle cell disease. Transfusion. 2020 Aug;60(8):1713-1722. doi: 10.1111/trf.15818. Epub 2020 Jun 24. PMID: 32579245.
Hb S/β-Thalassemia in the REDS-III Brazil Sickle Cell Disease Cohort: Clinical, Laboratory and Molecular Characteristics
Belisário AR, Carneiro-Proietti AB, Sabino EC, Araújo A, Loureiro P, Máximo C, Flor-Park MV, Rodrigues DDOW, Ozahata MC, McClure C, Mota RA, Gomes Moura IC, Custer B, Kelly S; Recipient Epidemiology and Donor Evaluation Study (REDS-III) International Component Brazil. Hb S/β-Thalassemia in the REDS-III Brazil Sickle Cell Disease Cohort: Clinical, Laboratory and Molecular Characteristics. Hemoglobin. 2020 Jan;44(1):1-9. doi: 10.1080/03630269.2020.1731530. Epub 2020 Mar 16. PMID: 32172616; PMCID: PMC7225056
Influence of sickle cell disease on susceptibility to HIV infection
Kelly S, Jacobs ES, Stone M, Keating SM, Lee TH, Chafets D, Heitman J, Dimapasoc M, Operskalski E, Hagar W, Vichinsky E, Busch MP, Norris PJ, Custer B; Recipient Epidemiology and Donor Evaluation Study (REDS-III). Influence of sickle cell disease on susceptibility to HIV infection. PLoS One. 2020 Apr 8;15(4):e0218880. doi: 10.1371/journal.pone.0218880. PMID: 32267841; PMCID: PMC7141606.
Use of an automated pyrosequencing technique for confirmation of sickle cell disease.
de Martino CC, Alencar CS, Loureiro P, Carneiro-Proietti ABF, Máximo CA, Mota RA, Rodrigues DOW, Gaburo Junior N, Kelly S, Sabino EC; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III). Use of an automated pyrosequencing technique for confirmation of sickle cell disease. PLoS One. 2019 Dec 12;14(12):e0216020. doi: 10.1371/journal.pone.0216020. PMID: 31830127; PMCID: PMC6907837.
Prevalence of serologic markers of transfusion and sexually transmitted infections and their correlation with clinical features in a large cohort of Brazilian patients with sickle cell disease.
Blatyta PF, Kelly S, Sabino E, Preiss L, Mendes F, Carneiro-Proietti AB, Werneck Rodrigues DO, Mota R, Loureiro P, Maximo C, Park M, Mendrone-Jr A, Gonçalez TT, de Almeida Neto C, Custer B; National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study III (REDS-III) International Component, Brazil. Prevalence of serologic markers of transfusion and sexually transmitted infections and their correlation with clinical features in a large cohort of Brazilian patients with sickle cell disease. Transfusion. 2020 Feb;60(2):343-350. doi: 10.1111/trf.15619. Epub 2019 Dec 5. PMID: 31804727.
Clinical and Genetic Predictors of Priapism in Sickle Cell Disease: Results from the Recipient Epidemiology and Donor Evaluation Study III Brazil Cohort Study.
Cintho Ozahata M, Page GP, Guo Y, Ferreira JE, Dinardo CL, Carneiro-Proietti ABF, Loureiro P, Mota RA, Rodrigues DOW, Belisario AR, Maximo C, Flor-Park MV, Custer B, Kelly S, Sabino EC; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III). Clinical and Genetic Predictors of Priapism in Sickle Cell Disease: Results from the Recipient Epidemiology and Donor Evaluation Study III Brazil Cohort Study. J Sex Med. 2019 Dec;16(12):1988-1999. doi: 10.1016/j.jsxm.2019.09.012. Epub 2019 Oct 24. PMID: 31668730; PMCID: PMC6904926.
Quality of life in pre-adolescent children with sickle cell disease in Brazil.
Oliveira CDL, Kelly S, de Almeida-Neto C, Carneiro-Proietti AB, Camargos Piassi FC, Salomon T, Flor-Park MV, Maximo C, Rodrigues DW, Mota RA, Teixeira CM, Loureiro P, Sabino EC, Custer B; Recipient Epidemiology and Donor Evaluation Study (REDS-III) International Component, Brazil. Quality of life in pre-adolescent children with sickle cell disease in Brazil. Pediatr Hematol Oncol. 2019 Nov;36(8):457-467. doi: 10.1080/08880018.2019.1660743. Epub 2019 Sep 6. PMID: 31490092; PMCID: PMC6872937.
Diversity of RH and transfusion support in Brazilian sickle cell disease patients with unexplained Rh antibodies.
Dinardo CL, Kelly S, Dezan MR, Ribeiro IH, Castilho SL, Schimidt LC, Valgueiro MDC, Preiss LR, Custer B, Sabino EC, Westhoff CM; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS)-III. Diversity of RH and transfusion support in Brazilian sickle cell disease patients with unexplained Rh antibodies. Transfusion. 2019 Oct;59(10):3228-3235. doi: 10.1111/trf.15479. Epub 2019 Aug 13. PMID: 31408202; PMCID: PMC6785370.
Identification and Characterization of Hematopoietic Stem Cell Transplant Candidates in a Sickle Cell Disease Cohort.
Flor-Park MV, Kelly S, Preiss L, Custer B, Carneiro-Proietti ABF, Araujo AS, Loureiro P, Maximo C, Rodrigues DOW, Mota RA, Sabino EC, Rocha V; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) – International Component Brazil. Identification and Characterization of Hematopoietic Stem Cell Transplant Candidates in a Sickle Cell Disease Cohort. Biol Blood Marrow Transplant. 2019 Oct;25(10):2103-2109. doi: 10.1016/j.bbmt.2019.06.013. Epub 2019 Jun 20. PMID: 31229639.
Deep sequencing of HIV-1 near full-length proviral genomes identifies high rates of BF1 recombinants including two novel circulating recombinant forms (CRF) 70_BF1 and a disseminating 71_BF1 among blood donors in Pernambuco, Brazil.
Pessôa R, Watanabe JT, Calabria P, Felix AC, Loureiro P, Sabino EC, Busch MP, Sanabani SS; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III. Deep sequencing of HIV-1 near full-length proviral genomes identifies high rates of BF1 recombinants including two novel circulating recombinant forms (CRF) 70_BF1 and a disseminating 71_BF1 among blood donors in Pernambuco, Brazil. PLoS One. 2014 Nov 17;9(11):e112674. doi: 10.1371/journal.pone.0112674. PMID: 25401747; PMCID: PMC4234413.
Contribution of the Retrovirus Epidemiology Donor Study (REDS) to research on blood transfusion safety in Brazil.
Loureiro P, de Almeida-Neto C, Proietti AB, Capuani L, Gonçalez TT, de Oliveira CD, Leão SC, Lopes MI, Sampaio D, Patavino GM, Ferreira JE, Blatyta PF, Lopes ME, Mendrone-Junior A, Salles NA, King M, Murphy E, Busch M, Custer B, Sabino EC. Contribution of the Retrovirus Epidemiology Donor Study (REDS) to research on blood transfusion safety in Brazil. Rev Bras Hematol Hemoter. 2014 Mar;36(2):152-8. doi: 10.5581/1516-8484.20140033. PMID: 24790542; PMCID: PMC4005515.
Enhanced detection of viral diversity using partial and near full-length genomes of human immunodeficiency virus Type 1 provirus deep sequencing data from recently infected donors at four blood centers in Brazil.
Pessôa R, Watanabe JT, Calabria P, Alencar CS, Loureiro P, Lopes ME, Proetti AB, Félix AC, Sabino EC, Busch MP, Sanabani SS; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Enhanced detection of viral diversity using partial and near full-length genomes of human immunodeficiency virus Type 1 provirus deep sequencing data from recently infected donors at four blood centers in Brazil. Transfusion. 2015 May;55(5):980-90. doi: 10.1111/trf.12936. Epub 2014 Nov 21. PMID: 25413141; PMCID: PMC4428985.
Transfusion-Transmitted Dengue and Associated Clinical Symptoms During the 2012 Epidemic in Brazil.
Sabino EC, Loureiro P, Lopes ME, Capuani L, McClure C, Chowdhury D, Di-Lorenzo-Oliveira C, Oliveira LC, Linnen JM, Lee TH, Gonçalez T, Brambilla D, Kleinman S, Busch MP, Custer B; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III. Transfusion-Transmitted Dengue and Associated Clinical Symptoms During the 2012 Epidemic in Brazil. J Infect Dis. 2016 Mar 1;213(5):694-702. doi: 10.1093/infdis/jiv326. Epub 2015 Jun 8. PMID: 26908780; PMCID: PMC4747611.
Ultra-Deep Sequencing of HIV-1 near Full-Length and Partial Proviral Genomes Reveals High Genetic Diversity among Brazilian Blood Donors.
Pessôa R, Loureiro P, Esther Lopes M, Carneiro-Proietti AB, Sabino EC, Busch MP, Sanabani SS. Ultra-Deep Sequencing of HIV-1 near Full-Length and Partial Proviral Genomes Reveals High Genetic Diversity among Brazilian Blood Donors. PLoS One. 2016 Mar 31;11(3):e0152499. doi: 10.1371/journal.pone.0152499. PMID: 27031505; PMCID: PMC4816342.
Duration of Dengue Viremia in Blood Donors and Relationships Between Donor Viremia, Infection Incidence and Clinical Case Reports During a Large Epidemic.
Busch MP, Sabino EC, Brambilla D, Lopes ME, Capuani L, Chowdhury D, McClure C, Linnen JM, Prince H, Simmons G, Lee TH, Kleinman S, Custer B; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Duration of Dengue Viremia in Blood Donors and Relationships Between Donor Viremia, Infection Incidence and Clinical Case Reports During a Large Epidemic. J Infect Dis. 2016 Jul 1;214(1):49-54. doi: 10.1093/infdis/jiw122. Epub 2016 Apr 1. PMID: 27302934; PMCID: PMC4907419.
Genomic and epidemiological characterisation of a dengue virus outbreak among blood donors in Brazil
Faria NR, da Costa AC, Lourenço J, Loureiro P, Lopes ME, Ribeiro R, Alencar CS, Kraemer MUG, Villabona-Arenas CJ, Wu CH, Thézé J, Khan K, Brent SE, Romano C, Delwart E, Custer B, Busch MP, Pybus OG, Sabino EC; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Genomic and epidemiological characterisation of a dengue virus outbreak among blood donors in Brazil. Sci Rep. 2017 Nov 9;7(1):15216. doi: 10.1038/s41598-017-15152-8. PMID: 29123142; PMCID: PMC5680240.
Clinical and genetic ancestry profile of a large multi-centre sickle cell disease cohort in Brazil.
Carneiro-Proietti ABF, Kelly S, Miranda Teixeira C, Sabino EC, Alencar CS, Capuani L, Salomon Silva TP, Araujo A, Loureiro P, Máximo C, Lobo C, Flor-Park MV, Rodrigues DOW, Mota RA, Gonçalez TT, Hoppe C, Ferreira JE, Ozahata M, Page GP, Guo Y, Preiss LR, Brambilla D, Busch MP, Custer B; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS-III). Clinical and genetic ancestry profile of a large multi-centre sickle cell disease cohort in Brazil. Br J Haematol. 2018 Sep;182(6):895-908. doi: 10.1111/bjh.15462. Epub 2018 Jul 19. PMID: 30027669.
HIV primary drug resistance and associated HIV risk factors among HIV positive blood donors in Brazil from 2007 to 2017
Moreira CHV, Salomon T, Alencar CS, Gonçalez TT, Sabino EC, Preiss L, Loureiro P, Lopes ME, Teixeira CM, Mundim M, Carneiro-Proietti AB, de Almeida-Neto C, Custer B. HIV primary drug resistance and associated HIV risk factors among HIV positive blood donors in Brazil from 2007 to 2017. Transfus Med. 2021 Apr;31(2):104-112. doi: 10.1111/tme.12766. Epub 2021 Mar 4. PMID: 33665900.
Association of HIV infection with clinical and laboratory characteristics of sickle cell disease
Belisário AR, Blatyta PF, Vivanco D, Oliveira CDL, Carneiro-Proietti AB, Sabino EC, de Almeida-Neto C, Loureiro P, Máximo C, de Oliveira Garcia Mateos S, Flor-Park MV, de Oliveira Werneck Rodrigues D, Afonso Mota R, Gonçalez TT, Hoffmann TJ, Kelly S, Custer B; Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) International Component Brazil. Association of HIV infection with clinical and laboratory characteristics of sickle cell disease. BMC Infect Dis. 2020 Aug 27;20(1):638. doi: 10.1186/s12879-020-05366-z. PMID: 32854639; PMCID: PMC7457248.
Characterization of HIV risks in a Brazilian sickle cell disease population
Blatyta PF, Kelly S, Goncalez TT, Carneiro-Proietti AB, Salomon T, Miranda C, Sabino E, Preiss L, Maximo C, Loureiro P, Custer B, de Almeida-Neto C; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) International Component, Brazil. Characterization of HIV risks in a Brazilian sickle cell disease population. BMC Public Health. 2020 Oct 23;20(1):1606. doi: 10.1186/s12889-020-09702-5. PMID: 33097032; PMCID: PMC7585195.
How Ancestry Influences the Chances of Finding Unrelated Donors: An Investigation in Admixed Brazilians
Nunes K, Aguiar VRC, Silva M, Sena AC, de Oliveira DCM, Dinardo CL, Kehdy FSG, Tarazona-Santos E, Rocha VG, Carneiro-Proietti ABF, Loureiro P, Flor-Park MV, Maximo C, Kelly S, Custer B, Weir BS, Sabino EC, Porto LC, Meyer D. How Ancestry Influences the Chances of Finding Unrelated Donors: An Investigation in Admixed Brazilians. Front Immunol. 2020 Nov 6;11:584950. doi: 10.3389/fimmu.2020.584950. PMID: 33240273; PMCID: PMC7677137.
10-year analysis of human immunodeficiency virus incidence in first-time and repeat donors in Brazil
de Oliveira Garcia Mateos S, Preiss L, Gonçalez TT, Di Lorenzo Oliveira C, Grebe E, Di Germanio C, Stone M, Amorim Filho L, Carneiro Proietti AB, Belisario AR, de Almeida-Neto C, Mendrone-Junior A, Loureiro P, Busch MP, Custer B, Cerdeira Sabino E; Recipient Epidemiology, Donor Evaluation Study (REDS-III) International Component Brazil. 10-year analysis of human immunodeficiency virus incidence in first-time and repeat donors in Brazil. Vox Sang. 2021 Feb;116(2):207-216. doi: 10.1111/vox.13002. Epub 2020 Sep 30. PMID: 32996602.
Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program
Dinardo CL, Oliveira TGM, Kelly S, Ashley-Koch A, Telen M, Schmidt LC, Castilho S, Melo K, Dezan MR, Wheeler MM, Johnsen JM, Nickerson DA, Jain D, Custer B, Pereira AC, Sabino EC; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS-III) International Component-Brazil, the Outcome Modifying Genes in SCD (OMG) study and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program Sickle Cell Disease Working Group. Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program. Transfusion. 2021 Feb;61(2):603-616. doi: 10.1111/trf.16204. Epub 2020 Nov 24. PMID: 33231305.
Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic
Buss LF, Prete CA Jr, Abrahim CMM, Mendrone A Jr, Salomon T, de Almeida-Neto C, França RFO, Belotti MC, Carvalho MPSS, Costa AG, Crispim MAE, Ferreira SC, Fraiji NA, Gurzenda S, Whittaker C, Kamaura LT, Takecian PL, da Silva Peixoto P, Oikawa MK, Nishiya AS, Rocha V, Salles NA, de Souza Santos AA, da Silva MA, Custer B, Parag KV, Barral-Netto M, Kraemer MUG, Pereira RHM, Pybus OG, Busch MP, Castro MC, Dye C, Nascimento VH, Faria NR, Sabino EC. Three-quarters attack rate of SARS-CoV-2 in the Brazilian Amazon during a largely unmitigated epidemic. Science. 2021 Jan 15;371(6526):288-292. doi: 10.1126/science.abe9728. Epub 2020 Dec 8. PMID: 33293339; PMCID: PMC7857406.
Surveillance for Zika, chikungunya and dengue virus incidence and RNAemia in blood donors at four Brazilian blood centers during 2016-2019
Custer B, Grebe E, Buccheri R, Bakkour S, Stone M, Capuani L, Alencar C, Amorim L, Loureiro P, Carneiro-Proietti AB, Mendrone-Junior A, Gonçalez T, Gao K, Livezey KW, Linnen JM, Brambilla D, McClure C, Busch MP, Sabino EC; Recipient Epidemiology and Donor Evaluation Study (REDS-III) International Component Brazil. Surveillance for Zika, chikungunya and dengue virus incidence and RNAemia in blood donors at four Brazilian blood centers during 2016-2019. J Infect Dis. 2022 Jun 11:jiac173. doi: 10.1093/infdis/jiac173. Epub ahead of print. PMID: 35687888.
Factors Associated with Leg Ulcers in Adults with Sickle Cell Disease in Brazil.
Souza VR, Kelly S, Sabino E, Oliveira F, Salomon T, Teixeira CM, Máximo C, Loureiro P, Carneiro-Proietti A B, Gomes I, Custer B, de Almeida-Neto C. to be submitted in Jan 2022
Is Severity Score Associated With Indication for Hematopoietic Stem Cell Transplantation in Individuals With Sickle Cell Anemia?
Flor-Park MV, Ozahata MC, Moura ICG, Blatyta P, Kelly S, Oliveira CDL, Capuani L, Belisário AR, Carneiro-Proietti ABF, Araujo AS, Loureiro P, Maximo C, Rodrigues DOW, Mota RA, Sabino E, Custer B, Rocha V; Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) International Component Brazil. Is Severity Score Associated With Indication for Hematopoietic Stem Cell Transplantation in Individuals With Sickle Cell Anemia? Transplant Cell Ther. 2022 Jul 3:S2666-6367(22)01434-8. doi: 10.1016/j.jtct.2022.06.024. Epub ahead of print. PMID: 35788087.
Prevalence and Risk Factors for Human T-Cell Lymphotropic Virus (HTLV) in Blood Donors in Brazil-A 10-Year Study (2007-2016)
Miranda C, Utsch-Gonçalves D, Piassi FCC, Loureiro P, Gomes I, Ribeiro MA, de Almeida-Neto C, Blatyta P, Amorim L, Garcia Mateos SO, Murphy EL, Custer B, Carneiro-Proietti ABF, Sabino EC. Prevalence and Risk Factors for Human T-Cell Lymphotropic Virus (HTLV) in Blood Donors in Brazil-A 10-Year Study (2007-2016). Front Med (Lausanne). 2022 Mar 9;9:844265. doi: 10.3389/fmed.2022.844265. PMID: 35355612; PMCID: PMC8959844.
China (Phases 1 and 2)
HIV prevalence and incidence estimates among blood donors in five regions in China
Shi L, Liu Y, Wang J, Zeng P, Gao Z, Wang S, Fu P, Liu J, Mao W, He W, Ma H, Huang M, Wan J, Liao D, Brambilla D, Sullivan M, Zou S, Ness P, He M, Shan H; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). HIV prevalence and incidence estimates among blood donors in five regions in China. Transfusion. 2020 Jan;60(1):117-125. doi: 10.1111/trf.15636. Epub 2019 Dec 16. PMID: 31845344.
Current risk factors for HIV infection among blood donors in seven Chinese regions
Zeng P, Liu J, Zhang C, Zhang B, Liu W, Huang M, Ma H, Zhao Y, Guo R, He M, Liu Y, Liao D, Sullivan M, Wang J, Cai W, Ness P, Shan H; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Current risk factors for HIV infection among blood donors in seven Chinese regions. Transfusion. 2020 Feb;60(2):326-333. doi: 10.1111/trf.15659. Epub 2020 Jan 8. PMID: 31912898.
Hepatitis C virus genotype/subtype distribution and evolution among Chinese blood donors: Revealing recent viral expansion
Zhang Y, Gao Z, Wang S, Liu J, Paul N, He T, Liu C, Zhang H, Lv Y, Cao R, Mao W, Wan J, Ma H, Huang M, Liu Y, Wang J, Liao P, Zeng P, He M, Shan H. Hepatitis C virus genotype/subtype distribution and evolution among Chinese blood donors: Revealing recent viral expansion. PLoS One. 2020 Jul 10;15(7):e0235612. doi: 10.1371/journal.pone.0235612. PMID: 32649673; PMCID: PMC7351211.
Hepatitis C virus prevalence and incidence estimates among Chinese blood donors.
Fu P, Lv Y, Zhang H, Liu C, Wen X, Ma H, He T, Ke L, Wu B, Liu J, He M, Liao D, Wang J, Ness P, Liu Y, Shan H; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Hepatitis C virus prevalence and incidence estimates among Chinese blood donors. Transfusion. 2019 Sep;59(9):2913-2921. doi: 10.1111/trf.15432. Epub 2019 Jul 4. PMID: 31271469.
A study of seroprevalence and rates of asymptomatic viremia of severe fever with thrombocytopenia syndrome virus among Chinese blood donors
Zeng P, Ma L, Gao Z, Wang J, Liu J, Huang X, Yang Q, Cao R, Wen X, Zhu L, Ma H, Yang Z, Lee TH, Brambilla D, Yuan M, Glynn S, Ness P, Kleinman S, Busch M, Shan H; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). A study of seroprevalence and rates of asymptomatic viremia of severe fever with thrombocytopenia syndrome virus among Chinese blood donors. Transfusion. 2015 May;55(5):965-71. doi: 10.1111/trf.12953. Epub 2014 Dec 15. PMID: 25496479; PMCID: PMC4428969.
Development and validation of a real-time reverse transcriptase PCR assay for sensitive detection of SFTSV.
Zeng P, Yang Z, Bakkour S, Wang B, Qing S, Wang J, Chen L, Busch M, Shan H, Liu J, Lee TH; International Component of the NHLBI Recipient Epidemiology Donor Evaluation Study-III (REDS-III). Development and validation of a real-time reverse transcriptase PCR assay for sensitive detection of SFTSV. J Med Virol. 2017 Jul;89(7):1131-1138. doi: 10.1002/jmv.24760. Epub 2017 Feb 27. PMID: 28036115; PMCID: PMC5422136.
Blood utilization in five Chinese hospitals shows low hemoglobin thresholds in medical patients.
Carson JL, Liu Y, Ness P, Zaccaro DJ, Wu B, Meng C, Zeng X, Qin L, Huang C, Zhou X, Xiong T, Li J, Xing J, Liao Q, Zheng Q, Zhang X, Wang J, Shan H. Blood utilization in five Chinese hospitals shows low hemoglobin thresholds in medical patients. Transfusion. 2019 Sep;59(9):2820-2826. doi: 10.1111/trf.15385. Epub 2019 May 31. PMID: 31150566.
South Africa (Phases 1 and 2)
A cross-sectional study of peripartum blood transfusion in the Eastern Cape, South Africa
Van den Berg K, Bloch EM, Aku AS, Mabenge M, Creel DV, Hofmeyr GJ, Murphy EL. A cross-sectional study of peripartum blood transfusion in the Eastern Cape, South Africa. S Afr Med J. 2016 Nov 2;106(11):1103-1109. doi: 10.7196/SAMJ.2016.v106i11.10870. PMID: 27842632; PMCID: PMC7202551.
Antenatal blood transfusion in South Africa: indications and practice in a high-HIV-prevalence setting
Bloch EM, Hull J, Green-Thompson R, Ingram C, Crookes RL, Fawcus S, Anthony J, Courtney L, Roubinian N, Jauregui A, Hilton JF, Murphy EL; NHLBI REDS-III South Africa Program. Antenatal blood transfusion in South Africa: indications and practice in a high-HIV-prevalence setting. Transfusion. 2020 Mar;60(3):479-487. doi: 10.1111/trf.15661. Epub 2020 Jan 7. PMID: 31909499.
HIV incidence in South African blood donors from 2012 to 2016: a comparison of estimation methods
Vermeulen M, Chowdhury D, Swanevelder R, Grebe E, Brambilla D, Jentsch U, Busch M, Van Zyl G, Murphy EL; REDS-III International Program South Africa. HIV incidence in South African blood donors from 2012 to 2016: a comparison of estimation methods. Vox Sang. 2020 Aug 6. doi: 10.1111/vox.12987. Epub ahead of print. PMID: 32762088.
Using a motivator and deterrent questionnaire to predict actual donation return behavior among first-time African-origin blood donors.
Swanevelder R, Reddy R, Chowdhury D, Olmsted M, Brambilla D, Jentsch U, Murphy EL; REDS-III South Africa Investigators. Using a motivator and deterrent questionnaire to predict actual donation return behavior among first-time African-origin blood donors. Transfusion. 2019 Sep;59(9):2885-2892. doi: 10.1111/trf.15436. Epub 2019 Jul 11. PMID: 31294464.
The impact of Human Immunodeficiency Virus infection on obstetric hemorrhage and blood transfusion in South Africa.
Bloch EM, Crookes RL, Hull J, Fawcus S, Gangaram R, Anthony J, Ingram C, Ngcobo S, Croxford J, Creel DV, Murphy EL; International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). The impact of human immunodeficiency virus infection on obstetric hemorrhage and blood transfusion in South Africa. Transfusion. 2015 Jul;55(7):1675-84. doi: 10.1111/trf.13040. Epub 2015 Mar 16. PMID: 25773233; PMCID: PMC4503480.
Motivators and deterrents to blood donation among Black South Africans: a qualitative analysis of focus group data.
Muthivhi TN, Olmsted MG, Park H, Sha M, Raju V, Mokoena T, Bloch EM, Murphy EL, Reddy R. Motivators and deterrents to blood donation among Black South Africans: a qualitative analysis of focus group data. Transfus Med. 2015 Aug;25(4):249-58. doi: 10.1111/tme.12218. Epub 2015 Jun 23. PMID: 26104809; PMCID: PMC4583344.
Use of Blood Donor Screening to Monitor Prevalence of HIV and Hepatitis B and C Viruses, South Africa.
Vermeulen M, Swanevelder R, Chowdhury D, Ingram C, Reddy R, Bloch EM, Custer BS, Murphy EL; NHLBI Recipient Epidemiology and Donor evaluation Study-III (REDS-III) International Component. Use of Blood Donor Screening to Monitor Prevalence of HIV and Hepatitis B and C Viruses, South Africa. Emerg Infect Dis. 2017 Sep;23(9):1560-1563. doi: 10.3201/eid2309.161594. PMID: 28820374; PMCID: PMC5572879.
Discovery of “false Elite Controllers”: HIV antibody-positive RNA-negative blood donors found to be on antiretroviral treatment.
Sykes W, Van den Berg K, Jacobs G, Jauregui A, Roubinian N, Wiesner L, Maartens G, Swanevelder R, Custer B, Busch M, Jentsch U, Murphy EL, Vermeulen M; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Discovery of False Elite Controllers: HIV Antibody-Positive RNA-Negative Blood Donors Found To Be on Antiretroviral Therapy. J Infect Dis. 2019 Jul 19;220(4):643-647. doi: 10.1093/infdis/jiz145. PMID: 30950501; PMCID: PMC6639597.
Implementation of a script for predonation interviews: impact on human immunodeficiency virus risk in South African blood donors.
Mitchel J, Custer B, Kaidarova Z, Murphy EL, van den Berg K; Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) South Africa Program. Implementation of a script for predonation interviews: impact on human immunodeficiency virus risk in South African blood donors. Transfusion. 2019 Jul;59(7):2344-2351. doi: 10.1111/trf.15288. Epub 2019 Apr 4. PMID: 30946490; PMCID: PMC6610781.
Risk factors for peripartum blood transfusion in South Africa: a case-control study.
Bloch EM, Ingram C, Hull J, Fawcus S, Anthony J, Green-Thompson R, Crookes RL, Ngcobo S, V Creel D, Courtney L, Bellairs GRM, Murphy EL; South Africa Program of the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Risk factors for peripartum blood transfusion in South Africa: a case-control study. Transfusion. 2018 Sep;58(9):2149-2156. doi: 10.1111/trf.14772. Epub 2018 Jul 10. PMID: 29989178; PMCID: PMC6167140.
Slower response to treatment of iron-deficiency anaemia in pregnant women infected with HIV: a prospective cohort study
Hull JC, Bloch EM, Ingram C, Crookes R, Vaughan J, Courtney L, Jauregui A, Hilton JF, Murphy EL; REDS-III South Africa Program. Slower response to treatment of iron-deficiency anaemia in pregnant women infected with HIV: a prospective cohort study. BJOG. 2021 Sep;128(10):1674-1681. doi: 10.1111/1471-0528.16671. Epub 2021 Mar 16. PMID: 33587784; PMCID: PMC8364561.
An international partnership was instrumental in building blood transfusion research capacity in South Africa
Jentsch U, van den Berg K, Swanevelder R, Vermeulen M, Reddy R, Murphy E. An international partnership was instrumental in building blood transfusion research capacity in South Africa. S Afr J Public Health. 2021 Apr;4(4):99.
Blood Center Testing Allows the Detection and Rapid Treatment of Acute and Recent HIV Infection
van den Berg K, Vermeulen M, Bakkour S, Stone M, Jacobs G, Nyoni C, Barker C, McClure C, Creel D, Grebe E, Roubinian N, Jentsch U, Custer B, Busch MP, Murphy EL, On Behalf Of The Recipient Epidemiology And Donor Evaluation Study Reds-Iii South Africa International Program. Blood Center Testing Allows the Detection and Rapid Treatment of Acute and Recent HIV Infection. Viruses. 2022 Oct 23;14(11):2326. doi: 10.3390/v14112326. PMID: 36366424; PMCID: PMC9698357.
Undisclosed HIV status and antiretroviral therapy use among South African blood donors
van den Berg K, Vermeulen M, Louw VJ, Murphy EL, Maartens G. Undisclosed HIV status and antiretroviral therapy use among South African blood donors. Transfusion. 2021 Aug;61(8):2392-2400. doi: 10.1111/trf.16571. Epub 2021 Jul 5. PMID: 34224581; PMCID: PMC8355170.
Association of ABO and RhD blood groups with the risk of HIV infection
Jacobs G, Van den Berg K, Vermeulen M, Swanevelder R, Custer B, Murphy EL. Association of ABO and RhD blood groups with the risk of HIV infection. PLoS One. 2023 Apr 26;18(4):e0284975. doi: 10.1371/journal.pone.0284975. PMID: 37099490; PMCID: PMC10132593.
A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors
Jentsch U, Vermeulen M, van den Berg K, Swanevelder R, Creel D, Jacobs G, Hemingway-Foday JJ, Nyoni C, Murphy EL, Custer B. A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors. Int J Infect Dis. 2024 Feb 17;141:106958. doi: 10.1016/j.ijid.2024.02.001. Epub ahead of print. PMID: 38373648.
Domestic – Phase 2
STRIPE
NT-proBNP levels in the identification and classification of pulmonary transfusion reactions
Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). NT-proBNP levels in the identification and classification of pulmonary transfusion reactions. Transfusion. 2020 Nov;60(11):2548-2556. doi: 10.1111/trf.16059. Epub 2020 Sep 9. PMID: 32905629.
Incidence of transfusion reactions: A multicenter study utilizing systematic active surveillance and expert adjudication.
Hendrickson JE, Roubinian NH, Chowdhury D, Brambilla D, Murphy EL, Wu Y, Ness PM, Gehrie EA, Snyder EL, George Hauser R, Gottschall JL, Kleinman S, Kakaiya R, Strauss RG; National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study (REDS-III). Incidence of transfusion reactions: a multicenter study utilizing systematic active surveillance and expert adjudication. Transfusion. 2016 Oct;56(10):2587-2596. doi: 10.1111/trf.13730. Epub 2016 Jul 26. PMID: 27460200; PMCID: PMC5559198.
Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm.
Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm. Vox Sang. 2017 Jan;112(1):56-63. doi: 10.1111/vox.12466. Epub 2016 Dec 21. PMID: 28001313; PMCID: PMC5257198.
Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload.
Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL; National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload. Crit Care Med. 2018 Apr;46(4):577-585. doi: 10.1097/CCM.0000000000002948. PMID: 29300236; PMCID: PMC5851817.
A multi-center study investigating vital sign changes occurring in complicated and uncomplicated transfusions.
Gehrie EA, Roubinian NH, Chowdhury D, Brambilla DJ, Murphy EL, Gottschall JL, Wu Y, Ness PM, Strauss RG, Hendrickson JE; NHLBI Recipient Epidemiology-Donor Evaluation Study (REDS-III). A multicentre study investigating vital sign changes occurring in complicated and uncomplicated transfusions. Vox Sang. 2018 Feb;113(2):160-169. doi: 10.1111/vox.12621. Epub 2017 Dec 25. PMID: 29277907; PMCID: PMC5812819.
Database analyses
The Epidemiology of Platelet Transfusions: an analysis of platelet use at 12 U.S. Hospitals
Gottschall J, Wu Y, Triulzi D, Kleinman S, Strauss R, Zimrin AB, McClure C, Tan S, Bialkowski W, Murphy E, Ness P; NHLBI Recipient Epidemiology and Donor Evaluation (REDS-III) Study. The epidemiology of platelet transfusions: an analysis of platelet use at 12 US hospitals. Transfusion. 2020 Jan;60(1):46-53. doi: 10.1111/trf.15637. Epub 2019 Dec 18. PMID: 31850522.
The evanescence and persistence of RBC alloantibodies in blood donors
Hauser RG, Esserman D, Karafin MS, Tan S, Balbuena-Merle R, Spencer BR, Roubinian NH, Wu Y, Triulzi DJ, Kleinman S, Gottschall JL, Hendrickson JE, Tormey CA; (for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)). The evanescence and persistence of RBC alloantibodies in blood donors. Transfusion. 2020 Apr;60(4):831-839. doi: 10.1111/trf.15718. Epub 2020 Feb 15. PMID: 32061102.
Equivalent inpatient mortality among direct-acting oral anticoagulant and warfarin users presenting with major hemorrhage.
Bialkowski W, Tan S, Mast AE, Kiss JE, Kor D, Gottschall J, Wu Y, Roubinian N, Triulzi D, Kleinman S, Choi Y, Brambilla D, Zimrin A; NHLBI Recipient Epidemiology and Donor Evaluation (REDS)-III Study. Equivalent inpatient mortality among direct-acting oral anticoagulant and warfarin users presenting with major hemorrhage. Thromb Res. 2020 Jan;185:109-118. doi: 10.1016/j.thromres.2019.11.024. Epub 2019 Nov 25. PMID: 31794885; PMCID: PMC7035631.
Association of donor age, body mass index, hemoglobin, and smoking status with in-hospital mortality and length of stay among red blood cell-transfused recipients.
Roubinian NH, Westlake M, St Lezin EM, Edgren G, Brambilla DJ, Lee C, Bruhn R, Cable RG, Triulzi DJ, Glynn SA, Kleinman S, Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Association of donor age, body mass index, hemoglobin, and smoking status with in-hospital mortality and length of stay among red blood cell-transfused recipients. Transfusion. 2019 Nov;59(11):3362-3370. doi: 10.1111/trf.15541. Epub 2019 Oct 11. PMID: 31602669; PMCID: PMC7029395.
Iron status and risk factors for iron depletion in a racially/ethnically diverse blood donor population.
Spencer BR, Guo Y, Cable RG, Kiss JE, Busch MP, Page GP, Endres-Dighe SM, Kleinman S, Glynn SA, Mast AE; National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Iron status and risk factors for iron depletion in a racially/ethnically diverse blood donor population. Transfusion. 2019 Oct;59(10):3146-3156. doi: 10.1111/trf.15448. Epub 2019 Jul 18. PMID: 31318071; PMCID: PMC7028389.
The impact of recipient factors on the lower-than-expected hemoglobin increment in transfused outpatients with hematologic diseases.
Karafin MS, Bruhn R, Roubinian NH, Chowdhury D, Qu L, Snyder EL, Murphy EL, Brambilla D, Cable RG, Hilton JF, St Lezin E; NHLBI Recipient Epidemiology and Donor Evaluation (REDS)-III Study. The impact of recipient factors on the lower-than-expected hemoglobin increment in transfused outpatients with hematologic diseases. Transfusion. 2019 Aug;59(8):2544-2550. doi: 10.1111/trf.15439. Epub 2019 Jul 4. PMID: 31270827.
Demographic and epidemiologic characterization of transfusion recipients from four U.S. regions: Evidence from the REDS-III Recipient Database.
Karafin MS, Bruhn R, Westlake M, Sullivan MT, Bialkowski W, Edgren G, Roubinian NH, Hauser RG, Kor DJ, Fleischmann D, Gottschall JL, Murphy EL, Triulzi DJ; National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Demographic and epidemiologic characterization of transfusion recipients from four US regions: evidence from the REDS-III recipient database. Transfusion. 2017 Dec;57(12):2903-2913. doi: 10.1111/trf.14370. Epub 2017 Oct 24. PMID: 29067705; PMCID: PMC5758361.
Prevalence and risk factors for RBC alloantibodies in blood donors in the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).
Karafin MS, Tan S, Tormey CA, Spencer BR, Hauser RG, Norris PJ, Roubinian NH, Wu Y, Triulzi DJ, Kleinman S, Gottschall JL, Hendrickson JE. Prevalence and risk factors for RBC alloantibodies in blood donors in the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Transfusion. 2019 Jan;59(1):217-225. doi: 10.1111/trf.15004. Epub 2018 Nov 14. PMID: 30427537.
Risk factors for red blood cell alloimmunization in the Recipient Epidemiology and Donor Evaluation Study (REDS-III) database.
Karafin MS, Westlake M, Hauser RG, Tormey CA, Norris PJ, Roubinian NH, Wu Y, Triulzi DJ, Kleinman S, Hendrickson JE; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Risk factors for red blood cell alloimmunization in the Recipient Epidemiology and Donor Evaluation Study (REDS-III) database. Br J Haematol. 2018 Jun;181(5):672-681. doi: 10.1111/bjh.15182. Epub 2018 Apr 19. PMID: 29675950; PMCID: PMC5991618.
Association of blood donor sex and prior pregnancy with mortality among red blood cell transfusion recipients.
Edgren G, Murphy EL, Brambilla DJ, Westlake M, Rostgaard K, Lee C, Cable RG, Triulzi D, Bruhn R, St Lezin EM, Erikstrup C, Ullum H, Glynn SA, Kleinman S, Hjalgrim H, Roubinian NH; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) Group. Association of Blood Donor Sex and Prior Pregnancy With Mortality Among Red Blood Cell Transfusion Recipients. JAMA. 2019 Jun 11;321(22):2183-2192. doi: 10.1001/jama.2019.7084. PMID: 31184739; PMCID: PMC6563535.
Red blood cell transfusion does not increase risk of venous or arterial thrombosis during hospitalization
Baumann Kreuziger, L, Edgren, G, Hauser, RG, et al. Red blood cell transfusion does not increase risk of venous or arterial thrombosis during hospitalization. Am J Hematol. 2021; 96: 218– 225. https://doi.org/10.1002/ajh.26038
RBC- Omics
Genetic and behavioral modification of hemoglobin and iron status among first-time and high-intensity blood donors
Mast AE, Langer JC, Guo Y, Bialkowski W, Spencer BR, Lee TH, Kiss J, Cable RG, Brambilla D, Busch MP, Page GP; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III. Genetic and behavioral modification of hemoglobin and iron status among first-time and high-intensity blood donors. Transfusion. 2020 Apr;60(4):747-758. doi: 10.1111/trf.15743. Epub 2020 Mar 12. PMID: 32163187; PMCID: PMC7393610.
Nicotine exposure increases markers of oxidant stress in stored red blood cells from healthy donor volunteers.
Stefanoni D, Fu X, Reisz JA, Kanias T, Nemkov T, Page GP, Dumont L, Roubinian N, Stone M, Kleinman S, Busch M, Zimring JC, D’Alessandro A; Recipient Epidemiology and Donor Evaluation Study-III (REDS III). Nicotine exposure increases markers of oxidant stress in stored red blood cells from healthy donor volunteers. Transfusion. 2020 Jun;60(6):1160-1174. doi: 10.1111/trf.15812. Epub 2020 May 8. PMID: 32385854.
Stored RBC metabolism as a function of caffeine levels.
D’Alessandro A, Fu X, Reisz JA, Kanias T, Page GP, Stone M, Kleinman S, Zimring JC, Busch M; Recipient Epidemiology and Donor Evaluation Study-III (REDS III). Stored RBC metabolism as a function of caffeine levels. Transfusion. 2020 Jun;60(6):1197-1211. doi: 10.1111/trf.15813. Epub 2020 May 11. PMID: 32394461.
Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity.
D’Alessandro A, Fu X, Kanias T, Reisz JA, Culp-Hill R, Guo Y, Gladwin MT, Page G, Kleinman S, Lanteri M, Stone M, Busch MP, Zimring JC; Recipient Epidemiology and Donor Evaluation Study-III (REDS III). Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity. Haematologica. 2021 May 1;106(5):1290-1302. doi: 10.3324/haematol.2020.246603. PMID: 32241843; PMCID: PMC8094095.
Ethyl-glucoronide, a marker of alcohol consumption, correlates with metabolic markers of oxidant stress in stored red blood cells from healthy blood donors.
D’Alessandro A, Fu X, Reisz JA, Stone M, Kleinman S, Zimring JC, Busch M; Recipient Epidemiology and Donor Evaluation Study-III (REDS III). Ethyl glucuronide, a marker of alcohol consumption, correlates with metabolic markers of oxidant stress but not with hemolysis in stored red blood cells from healthy blood donors. Transfusion. 2020 Jun;60(6):1183-1196. doi: 10.1111/trf.15811. Epub 2020 May 8. PMID: 32385922.
Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study.
Kanias T, Lanteri MC, Page GP, Guo Y, Endres SM, Stone M, Keating S, Mast AE, Cable RG, Triulzi DJ, Kiss JE, Murphy EL, Kleinman S, Busch MP, Gladwin MT. Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study. Blood Adv. 2017 Jun 27;1(15):1132-1141. doi: 10.1182/bloodadvances.2017004820. PMID: 29034365; PMCID: PMC5638435.
Piloting and implementation of quality assessment and quality control procedures in RBC-Omics: a large multi-center study of red blood cell hemolysis during storage.
Stone M, Keating SM, Kanias T, Lanteri MC, Lebedeva M, Sinchar D, Hampton D, Jakub A, Rychka V, Brewer G, Bakkour S, Gefter N, Murcia K, Page GP, Endres-Dighe S, Bialkowski W, Fu X, Zimring J, Raife TJ, Kleinman S, Gladwin MT, Busch MP; National Heart, Lung, and Blood Institute Recipient Epidemiology Donor Evaluation Study III (REDS-III) Program. Piloting and implementation of quality assessment and quality control procedures in RBC-Omics: a large multi-center study of red blood cell hemolysis during storage. Transfusion. 2019 Jan;59(1):57-66. doi: 10.1111/trf.15099. Epub 2018 Dec 19. PMID: 30566231.
Development and evaluation of a transfusion medicine genome wide genotyping array
Guo Y, Busch MP, Seielstad M, Endres-Dighe S, Westhoff CM, Keating B, Hoppe C, Bordbar A, Custer B, Butterworth AS, Kanias T, Mast AE, Kleinman S, Lu Y, Page GP; National Heart, Lung, and Blood Institute Recipient Epidemiology Donor Evaluation Study (REDS)-III. Development and evaluation of a transfusion medicine genome wide genotyping array. Transfusion. 2019 Jan;59(1):101-111. doi: 10.1111/trf.15012. Epub 2018 Nov 20. PMID: 30456907; PMCID: PMC7032526.
Intradonor reproducibility and changes in hemolytic variables during red blood cell storage: results of recall phase of the REDS-III RBC-Omics study.
Lanteri MC, Kanias T, Keating S, Stone M, Guo Y, Page GP, Brambilla DJ, Endres-Dighe SM, Mast AE, Bialkowski W, D’Andrea P, Cable RG, Spencer BR, Triulzi DJ, Murphy EL, Kleinman S, Gladwin MT, Busch MP; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III Program. Intradonor reproducibility and changes in hemolytic variables during red blood cell storage: results of recall phase of the REDS-III RBC-Omics study. Transfusion. 2019 Jan;59(1):79-88. doi: 10.1111/trf.14987. Epub 2018 Nov 8. PMID: 30408207; PMCID: PMC7007704.
Intradonor reproducibility and changes in hemolytic variables during RBC storage: a commom mistake in reproducibility analysis.
Naderi M, Sabour S. Intradonor reproducibility and changes in hemolytic variables during RBC storage: a common mistake in reproducibility analysis. Transfusion. 2019 Aug;59(8):2749-2750. doi: 10.1111/trf.15400. PMID: 31374149.
In response
Page GP, Brambilla DJ. In response. Transfusion. 2019 Aug;59(8):2750-2751. doi: 10.1111/trf.15418. PMID: 31374152.
Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics.
D’Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo Y, Page G, Gladwin MT, Kleinman S, Lanteri M, Stone M, Busch M, Zimring JC; Recipient Epidemiology and Donor Evaluation Study-III (REDS-III). Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics. Transfusion. 2019 Jan;59(1):89-100. doi: 10.1111/trf.14979. Epub 2018 Oct 24. PMID: 30353560; PMCID: PMC6322946.
Blood, Sweat and Tears: Red Blood Cell-Omics Study Objectives, Design, and Recruitment Activities
Endres-Dighe SM, Guo Y, Kanias T, Lanteri M, Stone M, Spencer B, Cable RG, Kiss JE, Kleinman S, Gladwin MT, Brambilla DJ, D’Andrea P, Triulzi DJ, Mast AE, Page GP, Busch MP; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III Program. Blood, sweat, and tears: Red Blood Cell-Omics study objectives, design, and recruitment activities. Transfusion. 2019 Jan;59(1):46-56. doi: 10.1111/trf.14971. Epub 2018 Sep 28. PMID: 30267427; PMCID: PMC6361628.
Frequent blood donations alter susceptibility of red blood cells to storage- and stress-induced hemolysis.
Kanias T, Stone M, Page GP, Guo Y, Endres-Dighe SM, Lanteri MC, Spencer BR, Cable RG, Triulzi DJ, Kiss JE, Murphy EL, Kleinman S, Gladwin MT, Busch MP, Mast AE; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III Program. Frequent blood donations alter susceptibility of red blood cells to storage- and stress-induced hemolysis. Transfusion. 2019 Jan;59(1):67-78. doi: 10.1111/trf.14998. Epub 2018 Nov 26. PMID: 30474858; PMCID: PMC6347021.
Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells.
Reisz JA, Nemkov T, Dzieciatkowska M, Culp-Hill R, Stefanoni D, Hill RC, Yoshida T, Dunham A, Kanias T, Dumont LJ, Busch M, Eisenmesser EZ, Zimring JC, Hansen KC, D’Alessandro A. Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. Transfusion. 2018 Dec;58(12):2978-2991. doi: 10.1111/trf.14936. Epub 2018 Oct 12. PMID: 30312994; PMCID: PMC6357231.
Diversity in a blood bag: application of omics technologies to inform precision Transfusion Medicine.
Kanias T, Busch MP; National Heart, Lung, and Blood Institute Recipient Epidemiology Donor Evaluation Study III (REDS-III) Programme. Diversity in a blood bag: application of omics technologies to inform precision Transfusion Medicine. Blood Transfus. 2019 Jul;17(4):258-262. doi: 10.2450/2019.0056-19. Epub 2019 Jun 5. PMID: 31184580; PMCID: PMC6683866. Blood Transfus Jun 5:1-5. doi:10.2450/2019.0056-19. PMID: 31184580.
Blood donor exposome and impact of common drugs on red blood cell metabolism
Nemkov T, Stefanoni D, Bordbar A, Issaian A, Palsson BO, Dumont LJ, Hay A, Song A, Xia Y, Redzic JS, Eisenmesser EZ, Zimring JC, Kleinman S, Hansen KC, Busch MP, D’Alessandro A; Recipient Epidemiology and Donor Evaluation Study III Red Blood Cell–Omics (REDS-III RBC-Omics) Study. Blood donor exposome and impact of common drugs on red blood cell metabolism. JCI Insight. 2021 Feb 8;6(3):e146175. doi: 10.1172/jci.insight.146175. PMID: 33351786; PMCID: PMC7934844.
Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage
Page GP, Kanias T, Guo YJ, Lanteri MC, Zhang X, Mast AE, Cable RG, Spencer BR, Kiss JE, Fang F, Endres-Dighe SM, Brambilla D, Nouraie M, Gordeuk VR, Kleinman S, Busch MP, Gladwin MT; National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology Donor Evaluation Study–III (REDS-III) program. Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage. J Clin Invest. 2021 Jul 1;131(13):e146077. doi: 10.1172/JCI146077. PMID: 34014839; PMCID: PMC8245173.
Demographic, clinical, and biochemical predictors of pica in a large cohort of blood donors
Liu H, Burns RT, Spencer BR, Page GP, Mast AE; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III. Demographic, clinical, and biochemical predictors of pica in a large cohort of blood donors. Transfusion. 2021 Jul;61(7):2090-2098. doi: 10.1111/trf.16409. Epub 2021 Apr 29. PMID: 33913181; PMCID: PMC8571648.
RETRO
Therapeutic impact of red blood cell transfusion on anemic outpatients: the RETRO study.
St Lezin E, Karafin MS, Bruhn R, Chowdhury D, Qu L, Bialkowski W, Merenda S, D’Andrea P, McCalla AL, Anderson L, Keating SM, Stone M, Snyder EL, Brambilla D, Murphy EL, Norris PJ, Hilton JF, Spencer BR, Kleinman S, Carson JL; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS)-III Program. Therapeutic impact of red blood cell transfusion on anemic outpatients: the RETRO study. Transfusion. 2019 Jun;59(6):1934-1943. doi: 10.1111/trf.15249. Epub 2019 Mar 18. PMID: 30882919; PMCID: PMC6548575.
Early and sustained improvement in fatigue-related quality of life following red blood cell transfusion in outpatients..
Bruhn R, Karafin MS, Hilton JF, Kaidarova Z, Spencer BR, Qu L, Snyder EL, Olin R, Murphy EL, St Lezin E; NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS)-III Program. Early and sustained improvement in fatigue-related quality of life following red blood cell transfusion in outpatients. Qual Life Res. 2020 May 7. doi: 10.1007/s11136-020-02517-2. Epub ahead of print. PMID: 32382935.
HEIRS
The benefits of iron supplementation following blood donation vary with baseline iron status
Mast AE, Szabo A, Stone M, Cable RG, Spencer BR, Kiss JE; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III. The benefits of iron supplementation following blood donation vary with baseline iron status. Am J Hematol. 2020 Jul;95(7):784-791. doi: 10.1002/ajh.25800. Epub 2020 Apr 15. PMID: 32243609; PMCID: PMC7393577.
CHILL
REDS-III RBC-Omics Samples and Data Acknowledgement
Impact of Taurine on Red Blood Cell Metabolism and implications to blood storage
Bertolone L, Roy MK, Hay AM, Morrison EJ, Stefanoni D, Fu X, Kanias T, Kleinman S, Dumont LJ, Stone M, Nemkov T, Busch MP, Zimring JC, D’Alessandro A. Impact of taurine on red blood cell metabolism and implications for blood storage. Transfusion. 2020 Jun;60(6):1212-1226. doi: 10.1111/trf.15810. Epub 2020 Apr 27. PMID: 32339326; PMCID: PMC7995806.
Genetic analysis of the Brazil SCD cohort using whole genome sequencing – part of the TOPMed program
Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program
Dinardo CL, Oliveira TGM, Kelly S, Ashley-Koch A, Telen M, Schmidt LC, Castilho S, Melo K, Dezan MR, Wheeler MM, Johnsen JM, Nickerson DA, Jain D, Custer B, Pereira AC, Sabino EC; NHLBI Recipient Epidemiology Donor Evaluation Study (REDS-III) International Component-Brazil, the Outcome Modifying Genes in SCD (OMG) study and the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program Sickle Cell Disease Working Group. Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program. Transfusion. 2021 Feb;61(2):603-616. doi: 10.1111/trf.16204. Epub 2020 Nov 24. PMID: 33231305.
Chronological storage age and metabolic age of stored red blood cells: are they the same?
D’Alessandro A, Zimring JC, Busch M. Chronological storage age and metabolic age of stored red blood cells: are they the same? Transfusion. 2019 May;59(5):1620-1623. doi: 10.1111/trf.15248. Epub 2019 Mar 13. PMID: 30865302.
Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality
Thomas T, Cendali F, Fu X, Gamboni F, Morrison EJ, Beirne J, Nemkov T, Antonelou MH, Kriebardis A, Welsby I, Hay A, Dziewulska KH, Busch MP, Kleinman S, Buehler PW, Spitalnik SL, Zimring JC, D’Alessandro A. Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality. Transfusion. 2021 Jun;61(6):1867-1883. doi: 10.1111/trf.16402. Epub 2021 Apr 26. PMID: 33904180; PMCID: PMC8217387.
The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality
Issaian A, Hay A, Dzieciatkowska M, Roberti D, Perrotta S, Darula Z, Redzic J, Busch MP, Page GP, Rogers SC, Doctor A, Hansen KC, Eisenmesser EZ, Zimring JC, D’Alessandro A. The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality. Haematologica. 2021 Nov 1;106(11):2971-2985. doi: 10.3324/haematol.2020.278252. PMID: 33979990; PMCID: PMC8561282.
Clonal hematopoiesis in sickle cell disease
Liggett LA, Cato LD, Weinstock JS, Zhang Y, Nouraie SM, Gladwin MT, Garrett ME, Ashley-Koch A, Telen MJ, Custer B, Kelly S, Dinardo CL, Sabino EC, Loureiro P, Carneiro-Proietti AB, Maximo C; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Reiner AP, Abecasis GR, Williams DA, Natarajan P, Bick AG, Sankaran VG. Clonal hematopoiesis in sickle cell disease. J Clin Invest. 2022 Feb 15;132(4):e156060. doi: 10.1172/JCI156060. PMID: 34990411; PMCID: PMC8843701.
Reprogramming of red blood cell metabolism in Zika virus-infected donors
Catala A, Stone M, Busch MP, D’Alessandro A. Reprogramming of red blood cell metabolism in Zika virus-infected donors. Transfusion. 2022 May;62(5):1045-1064. doi: 10.1111/trf.16851. Epub 2022 Mar 14. PMID: 35285520; PMCID: PMC9086146.
Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors.
Moore A, Busch MP, Dziewulska K, Francis RO, Hod EA, Zimring JC, D’Alessandro A, Page GP. Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors. J Biol Chem. 2022 Dec;298(12):102706. doi: 10.1016/j.jbc.2022.102706. Epub 2022 Nov 15. PMID: 36395887; PMCID: PMC9763692.
Effect of surreptitious ART on recency assays; Karin vandenBerg et al
Elevated risk for iron depletion in high-school age blood donors.
Spencer BR, Bialkowski W, Creel DV, Cable RG, Kiss JE, Stone M, McClure C, Kleinman S, Glynn SA, Mast AE; National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) Program. Elevated risk for iron depletion in high-school age blood donors. Transfusion. 2019 May;59(5):1706-1716. doi: 10.1111/trf.15133. Epub 2019 Jan 11. PMID: 30633813; PMCID: PMC6499707.
Abstract Presentations – American Association of Blood Banks (AABB)
Annual Meeting 2017
Zika, Chikungunya and Dengue Virus Incident Infections in Blood Donors in Brazil in 2016: Implications for Blood Safety and Public Health Surveillance
B Custer, T Goncalez, K Gao, D Brambilla, A Carneiro Proietti, A Mendrone, P Loureiro, M E Lopes, L Capuani, M P Busch, E Sabino, and REDS-III International Brazil.
Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload during a Period of Decreased Blood Utilization
N Roubinian, J Hendrickson, D Triulzi, J Gottschall, M Michalkiewicz, D Chowdhury, D J Kor, M R Looney, M Matthay, S Kleinman, D Brambilla and E Murphy.
A Multi-Center Study Investigating Vital Sign Changes Occurring in Complicated and Uncomplicated Transfusions
E Gehrie, N Roubinian, D Chowdhury, D Brambilla, E Murply, J Gottschall, Y Wu, P M Ness, R G Strauss and J Hendrickson.
Elevated Risk for Iron Depletion in High School Blood Donors
B R Spencer, W Bialkowski, R G Cable, J E Kiss, D Creel, M Stone, C McClure, S Kleinman, S Glynn, A Mast and for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).
Using a Motivator and Deterrent Questionnaire to Predict Actual Donation Return Behavior Among First-Time Black Blood Donors in South Africa
R Swanevelder, R Reddy, D Chowdhury, D Brambilla and E L Murphy.
Zika RNA Persistence in Blood and Body Fluids and Clinical Outcomes in Infected Blood Donors
M Stone, S Bakkour, T Lee, M Lanteri, G Simmons, D Brambilla, J O Alsina, P C Williamson, R A Reik, S A Galel, J Linnen, S Kleinman, M P Busch and for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).
Iron Status and Novel Risk Factors for Iron Depletion in a Diverse Donor Population
B R Spencer, Y Guo, R G Cable, J E Kiss, M P Busch, G Page, S Endres-Dighe, S Kleinman, S Glynn, A Mast and for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).
Understanding Iron Deficiency Anemia Among HIV Positive and Negative Pregnant Women in South Africa: A First Step Toward Prevention of Peripartum Blood Transfusion
J C Hull, E M Bloch, C Ingram, R Crookes, N Mack, L Courtney, and E L Murphy.
Predictors of Red Blood Cell Alloimmunization in a Brazilian Sickle Cell Disease (SCD) Cohort
S Kelly, L Preiss, C Dinardo, S Lopes de Castilho, M do Carmo Valgueiro, L Cayres, Y Guo, E Sabino, G Page, B Custer and REDS-III International-Brazil.
Abstract Presentations – American Society of Hematology (ASH)
Annual Meeting 2017
GWAS of Complete Blood Count (CBC) Measures in 13,403 Blood Donors in the Multi-racial RBC-Omics Study Reveal Novel Genetic Loci in Minority Populations which Provide Insights into the Pathways that may Connect Them to Disease
Y Guo; GP Page; AE Mast; RG Cable; BR Spencer; JE Kiss; S Endres-Dighe; S Kleinman; and M Busch; for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).
Effect of RBC Transfusion on Six Minute Walk Test Performance and Quality of Life in Outpatients
E St. Lezin, M Karafin, R Bruhn, D Chowdhury, L Qu, W Bialkowski, S Merenda, L Anderson, P D’Andrea, A McCalla, EL Snyder, EL Murphy, D Brambilla, PL Norris, BR Spencer, S Kleinman, JL Carson, for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).
Epidemiologic Characterization of Transfusion Recipients with Red Blood Cell Alloantibodies from four US Regions: Evidence from the REDS-III Recipient Database
MA Karafin, M Westlake, RG Hauser, CA Tormey, PJ Norris, NH Roubinian, Y Wu, S Kleinman, JE Hendrickson, for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).
The Epidemiology of Platelet Transfusions: An analysis of platelet use at 12 US hospitals
J Gottschall, Y Wu, D Triulzi, EL Murphy, PM Ness, RG Strauss, S Kleinman, AB Zimrin, C McClure, S Tan for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) .
Abstract Presentations – American Association of Blood Banks (AABB)
Annual Meeting 2016
Hepatitis B Virus Prevalence in Chinese Blood Donors: HBsAg-reactive rates from Pre-donation Rapid Test and Post-donation Screening Test
M He, J E Liu, Y Liu, W Mao, T He, M Huang, R Cao, D Liao, J Wang, H Shan.
ABO and RhD Blood Groups and Susceptibility to HIV Infection among South African Blood Donors
G A Beck, M Vermeulen, D Chowdhury, C F Ingram, R Reddy, B Custer, E L Murphy.
Peripartum Blood Transfusion in South Africa: An Association between HIV Infection and Risk of Transfusion
E Bloch, C F Ingram, J Hull, S Fawcus, J Anthony, R Green-Thompson, R Crookes, S M Ngcobo, D Creel, L C Courtney, E L Murphy.
Inflammatory and Cardiopulmonary Biomarker Characterization of Pulmonary Transfusion Reactions
N Roubinian, M Looney, P Toy, S Keating, P J Norris, C Lowell, D Kor, O Gajic, R Hubmayr, M Gropper, G Wilson, M Matthay, E Murphy.
Development and Evaluation of a Transfusion Medicine Genome-wide SNP Array
G P Page, Y Guo, M Seielstad, B Keating, C M Westhoff, C Hoppe, A Bordbar, B Custer, Y Lu, M Busch for the NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).
Oral Presentations
Incidence of Transfusion Reactions: A Multicenter Study Utilizing Systematic Active Surveillance and Expert Adjudication
J E Hendrickson, N Roubinian, D Chowdhury, D Brambilla, E Murphy, Y Wu, P M Ness, E Gehrie, E Snyder, R G Hauser, J Gottschall, S Kleinman, R Kakaiya, R Strauss.
Effect of Age, Sex, or Frequency of Blood Donations on Donors’ Ferritin Levels and RBC Storage Stability
T Kanias, M C Lanteri, S Keating, G P Page, D Brambilla, S M Endres, A E Mast, R G Cable, D J Triulzi, J E Kiss, M T Gladwin, S Kleinman, M Busch.
Abstract Presentations – American Association of Blood Banks (AABB)
Annual Meeting 2015
Genetic, Ethnic and Gender Determinants of Red Blood Cell Storage and Stress Hemolysis
T Kanias, M C Lanteri, SM Keating, D Brambilla, S M Endres, S H Kleinman, M T Gladwin, M P Busch, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Incidence and Clinical Characteristics of Transfusion-Associated Circulatory Overload (TACO) by Using an Electronic Health Record Surveillance Algorithm
N Roubinian, J E Hendrickson, J Gottschall, D Triulzi, D J Kor, D Chowdhury, S H Kleinman, E L Murphy, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Establishing a Multicenter Transfusion Recipient Database: Feasibility and Potential Use
M S Karafin, R Bruhn, N Roubinian, M Westlake, J Gottschall, D J Kor, D Fleischmann, R Hauser, E L Murphy, D Triulzi, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Hemoglobin Triggers for Red Blood Cell Transfusion in the NHLBI Recipient Epidemiology and Donor Evaluation Study III (REDS-III) Program Transfusion Recipient Database
R Bruhn, M S Karafin, N Roubinian, M Westlake, J Gottschall, D J Kor, D Fleischmann, E L Murphy, D Triulzi, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Prevalence of HIV, Hepatitis B and C viruses in South African Blood Donors, 2012-2014
M Vermeulen, R Swanevelder, D Chowdhury, C Ingram, V Reddy, T Muthivhi, E Bloch, B Custer, E L Murphy, for the International Component of NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
The Staging, Genotypic Distribution and Drug Resistance Mutation Profiles of HIV among Infected Blood Donors from Five Chinese Blood Centers, 2012-2014
P Zeng, J Wang, J Liu, W Mao, X Bi, J Li, L Zhu, R Cao, D Liao, H Shan, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Frequency of Anti-HIV Confirmed by Western Blot and Donor Characteristics at Five Chinese Blood Centers
Z Gao, M He, J Wang, J Liu, T He, J Xu, Y Lv, X Wen, H Zhang, H Shan, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Variability in HIV Prevalence and Incidence among First-time Blood Donors in Brazil Before and After Introduction of NAT
E C Sabino, B Custer, S M Keating, L Preiss, A Mendrone, L Amorim, A Carneiro Proietti, P Loureiro, M K Oikawa, D Brambilla, M P Busch, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Intra-donor Reproducibility and Changes in Hemolytic Parameters during RBC storage
M C Lanteri, T Kanias, S M Keating, D Brambilla, B R Spencer, W Bialkowski, P D’Andrea, S H Kleinman, M T Gladwin, M P Busch, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Abstract Presentations – American Society of Hematology (ASH)
Annual Meeting 2014
Effects of Storage Iron on Erythropoietin and Hepcidin Responses to Acute Hemorrhage
A E Mast, J Kiss, R G Cable, S Glynn, and Donald Brambilla, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Downregulation of cytokines and chemokines by GB virus C after transfusion-transmission in HIV + blood recipient
M C. Lanteri, F Vahidnia, S Tan, J T Stapleton, P J Norris, J Heitman, X Deng, S Keating, D Brambilla, M P Busch, B Custer, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Abstract Presentations – American Association of Blood Banks (AABB)
Annual Meeting 2014
Symptoms and Outcomes of Dengue Among Transfusion Recipients in Brazil who were RNA+ of Who Received an RNA+ unit Compared to RNA- Recipients
E C Sabino, C D Oliveira, P Loureiro, M Lopes, L D Capuani, C McClure, D Chowdhury, S Kleinman, M Busch, B Custer, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Noncompliance with the Men Who Have Sex with Men (MSM) Deferral among Male U.S. Blood Donors
B Custer, N Sheon, B Siedle-Khan, L M Pollack, B R Spencer, W Bialkowski, P A D’Andrea, M Sullivan, S Glynn, A Williams, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Quantification of Iron Stores, Body Iron, and Iron Absorption in Blood Donors: Effect on Iron Supplementation
R G Cable, D Brambilla, S Glynn, A E Mast, J E Kiss, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
High Proportion of Anti-HCV EIA False-positive Results among Chinese Blood Donors: A Multi-center Study
M He, Z Gao, D Chowdhury, J Wang, W Mao, Y Lv, X Bi, R Cao, J Xu, H Shan, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Screening and Confirmatory Test-Positive Rates of HBsAg among Blood Donors from Five Chinese Blood Centers
Y Liu, M He, J Liu, H Liao, L Zhu, X Li, X Wen, J Li, D Chowdhury, H Shan, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Seroprevalence and Rates of Asymptomatic Viremia of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) in Chinese Blood Donors
P Zeng, J Wang, X Huang, R Cao, L Zhu, T Lee, J Liu, M Yuan, P M Ness, H Shuan, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Abstract Presentations – American Society of Hematology (ASH)
Annual Meeting 2013
The TMPRSS6 Ala736Val Polymorphism is Associated with Decreased Hemoglobin and Iron Status in Females Undergoing Repeated Phlebotomy
AE Mast, J Langer, W Bialkowski, S Glynn, TH Lee, JE Kiss, RG Cable, M Busch, D Brambilla, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Abstract Presentations – International Society of Blood Transfusion (ISBT)
Annual Meeting 2013
Predicting Red Blood Cell Transfusion in Hospitalized Patients using Electronic Medical Records
NH Roubinian, EL Murphy, BE Swain, MN Gardner, D Triulzi, JL Gottschall, B Custer, R Bruhn, J Carson, SH Kleinman, V Liu, GJ Escobar, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Motivators and Deterrents to Blood Donation among Black South Africans: A Qualitative Analysis of Focus Group Data
R Reddy, M Olmsted, T Muthivhi, H Park, M Sha, T Mokoena, V Raju, K Mathavha, B Russell, E Bloch, R Crookes, EL Murphy, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
The Impact of HIV Infection in Obstetric Hemorrhage and Blood Transfusion in South Africa
EM Bloch, R Crookes, J Hull, R Gangaram, S Fawcus, J Anthony, C Ingram, S Ngcobo, JA Croxford, D Creel, EL Murphy, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Dengue RNA among blood donors and recipients during large epidemics of DEN4 in Rio de Janeiro and Recife, Brazil
EC Sabino, P Loureiro, ME Lopes, L Capuani, C Oliveira, L Oliveira, L Ferreira, H Domingues, TH Lee, T Gonçalez, B Custer, M Busch, D Brambilla, D Chowdhury, C McClure, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
An analysis of blood donor informed consent for future use of samples collected during a transfusion-transmitted infectious disease study in two blood banks in Brazil
L Capuani, P Loureiro, I Gerreiro, ME Lopes, C Di Lorenzo, H Domingues, T Gonçalez, C McClure, B Custer, EC Sabino, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Prevalence of Symptomatic Dengue Virus Infection in Transfused Patients
B Custer, EC Sabino, C McClure, D Chowdhury, P Loureiro, M Lopes, C Lorenzo, L Capuani, T Gonçalez, J Linnen and M Busch, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Abstract Presentations – American Association of Blood Banks (AABB)
Annual Meeting 2013
Hemoglobin Recovery after Blood Donation and the Effects of Iron Supplementation: The Hemoglobin and Iron Recovery Study (HEIRS)
JE Kiss, RG Cable, D Brambilla, S Glynn, AE Mast, BR Spencer, M Stone, LH Tobler, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
A Descriptive Analysis of Plasma use in the REDS-III Hospital Network
D Triulzi, J Gottschall, EL Murphy, E Fiebig, Y Wu, PM Ness, D Kor, D Chowdhury, D Fleischman, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Genome-Wide Association Study of HLA Allo-Antibody Formation and Persistence
M Seielstad, G Page, N Gaddis, X Deng, T Lee, MC Lanteri, Y Wu, R Kakaiya, MP Busch, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Predictors of Venous Hemoglobin in the Week Following Whole Blood Donation
RG Cable, D Brambilla, S Glynn, JE Kiss, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Racial Differences in Syncope Rates among South African Blood Donors
K Van den Berg, E Bloch, N Moleli, C Ingram, R Swanevelder, T Muthivhi, J Langer, B Custer, EL Murphy, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Peripartum Blood Transfusion in South Africa: Contributions of Prenatal Anemia, Obstetric Hemorrhage, and Inter-Hospital Variation
JC Hull, R Gangaram, S Fawcus, J Anthony, E Bloch, R Crookes, C Ingram, SM Ngcobo, JA Croxford, EL Murphy, for the International Component of the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Transfusion Epidemiology of Hospitalized Patients in the United States: Data from an Integrated Health Care Delivery System
N Roubinian, GJ Escobar, BE Swain, MN Gardner, V Liu, DJ Triulzi, J Gottschall, Y Wu, S Kleinman, EL Murphy, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).
Abstract Presentations – American Association of Blood Banks (AABB)
Annual Meeting 2012
Sources of Variation in Plasma Ferretin Levels Relevant to Use of Ferritin for Monitoring Iron Stores in Blood Donors
M Stone, K Murcia, P Loanzon, RG Cable, JE Kiss, D Brambilla, L Tobler, M Busch, for the NHLBI Recipient Epidemiology and Donor Evaluation Study – III (REDS-III).